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Poop pills

GK4Herd

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Aug 5, 2001
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Anyone noticing the spike of articles on gut microbes and its role in obesity? I've noticed a ton of articles over the last year about this fairly new field of study. It's in its infancy but the findings are interesting. The link to how the unique gut biome of individuals are playing a part in health is showing some promising results. Here's a bit from the article I'll link at the bottom...


A few years ago, researchers took the gut microbes from a set of twins—one lean, one obese—and transplanted them into two sets of microbe-free mice. Even though all the mice were on the same diet, the rodents that received the obese twin’s microbes became chubby. The mice that got the lean twin’s mix stayed slim, suggesting that the microbes were calling the shots when it came to the animals’ weight.

In line with those results, another study on lean and obese twins’ microbes suggested that obesity is linked to having altered mixes and lower diversity of gut microbes.

There was also a concerning case last year in which microbes seemed to hijack a woman’s weight after a fecal matter transplant (FMT). She underwent the FMT to treat a recurring intestinal infection from Clostridium difficile. The fecal donor was the woman’s daughter, who was overweight but otherwise healthy. After the transplant, the woman was cured of her infection, but inexplicably gained weight.


Like I said, the field is in its infancy so much is being discovered. But fecal transplants and "poop pills" are starting to become a thing. There's a plethora of articles out there. Just something kinda new hitting the scene.

Freeze dried poop pills being tested for obesity treatment...

http://arstechnica.com/science/2016/01/freeze-dried-poop-pills-being-tested-for-obesity-treatment/
 
The guy biome is very interesting for sure but the whole idea of poop pills and fecal transplants turns my stomach and sounds absolutely disgusting to me
 
Do we really think these piece of shit pills will really work?

Will work doing what? Losing weight? Gaining weight? Curing intestinal infections? It's already being used to successfully treat Colitis and other intestinal infections. The effective rate has been as high as 85% for success and isn't prone to antibiotic resistance like treatment by antibiotics can lead to,

And as far as weight loss...human trials are already under way. From an article...

The million-dollar question: Are poo transplants an effective intervention for weight problems? Though they’re not a cure for obesity, they appear to be capable of shifting one toward a lean metabolism. In 2010, a double-blind randomized controlled trial on the use of FBT for diabetes and obesity was conducted in 18 male subjects. Half received fecal material from lean male donors; half were implanted with their own feces. After 6 weeks, those who received fecal transplants from lean donors saw a marked reduction in fasting triglyceride levels and significant improvement in insulin sensitivity. (Vrieze A, Holleman F, Zoetendal EG, de Vos WM, Hoekstra JB, Nieuwdorp M. The environment within: how gut microbiota may influence metabolism and body composition. Diabetologia. 2010;53(4):606-13. El-Matary W, Simpson R, Ricketts-Burns N.). This is a small test group, but the results were replicated in a similar follow-up study by the same researchers, so the science is promising.


No one is really calling this some kind of miracle weight loss deal and the safety of it hasn't really been tested so we're a long way off from knowing enough about it, but there's definitely been a lot of noise in the medical community in the last year.


 
Will work doing what? Losing weight? Gaining weight? Curing intestinal infections? It's already being used to successfully treat Colitis and other intestinal infections. The effective rate has been as high as 85% for success and isn't prone to antibiotic resistance like treatment by antibiotics can lead to,

And as far as weight loss...human trials are already under way. From an article...

The million-dollar question: Are poo transplants an effective intervention for weight problems? Though they’re not a cure for obesity, they appear to be capable of shifting one toward a lean metabolism. In 2010, a double-blind randomized controlled trial on the use of FBT for diabetes and obesity was conducted in 18 male subjects. Half received fecal material from lean male donors; half were implanted with their own feces. After 6 weeks, those who received fecal transplants from lean donors saw a marked reduction in fasting triglyceride levels and significant improvement in insulin sensitivity. (Vrieze A, Holleman F, Zoetendal EG, de Vos WM, Hoekstra JB, Nieuwdorp M. The environment within: how gut microbiota may influence metabolism and body composition. Diabetologia. 2010;53(4):606-13. El-Matary W, Simpson R, Ricketts-Burns N.). This is a small test group, but the results were replicated in a similar follow-up study by the same researchers, so the science is promising.


No one is really calling this some kind of miracle weight loss deal and the safety of it hasn't really been tested so we're a long way off from knowing enough about it, but there's definitely been a lot of noise in the medical community in the last year.
Aren't the freeze dried pills gut cultures? Aka pieces of shit..... TE he
 
True story - One of my co residents (while he was a lowly intern) donated his poop to a patient on his service with a refractory case of c diff. Patient got a rectal infusion/fecal transplant and got better.

He called the patient his "mud brother."
 
Eventually (at least I think) research data will confirm that much of the gut-bacteria problem will be tied to the anti-bacterial everything crazes of the last decade plus. The last generation or so of children has been deprived of playing in dirt, eating dirt, feeling dirt, bathing in dirt, and now these children have untold numbers of intestinal and digestive issues.

/rant off
 
Eventually (at least I think) research data will confirm that much of the gut-bacteria problem will be tied to the anti-bacterial everything crazes of the last decade plus. The last generation or so of children has been deprived of playing in dirt, eating dirt, feeling dirt, bathing in dirt, and now these children have untold numbers of intestinal and digestive issues.

/rant off

It's just our culture....:)
 
Eventually (at least I think) research data will confirm that much of the gut-bacteria problem will be tied to the anti-bacterial everything crazes of the last decade plus. The last generation or so of children has been deprived of playing in dirt, eating dirt, feeling dirt, bathing in dirt, and now these children have untold numbers of intestinal and digestive issues.

/rant off
Vaginifaction of America can lead to health issues. This proves it.
 
Eventually (at least I think) research data will confirm that much of the gut-bacteria problem will be tied to the anti-bacterial everything crazes of the last decade plus. The last generation or so of children has been deprived of playing in dirt, eating dirt, feeling dirt, bathing in dirt, and now these children have untold numbers of intestinal and digestive issues.

/rant off

Like many things, it's probably a combination of things:

1. Poor diet.
2. Ubiquitous use of antibiotics (by physicians and in agriculture/livestock)
3. Lack of dirt/lack of exposure
 
True story - One of my co residents (while he was a lowly intern) donated his poop to a patient on his service with a refractory case of c diff. Patient got a rectal infusion/fecal transplant and got better.

He called the patient his "mud brother."

How does a person actually go about becoming a poop donor? I mean...is there a place that you can actually go to just like a sperm bank? Well...without the magazines and everything.
 
And on a serious note Carl...being a doctor, what are your thoughts on these studies finding evidence that our gut biome might be important in weight gain or loss? I have lived the last year using the premise calories in-calories out. That seems to be the key at the end of the day. So after a year of walking daily (my Fitbit history has me at over 43,150,000 steps in the last year), lifting weights four days a week, and counting calories daily I've lost about 40 pounds. But after loosening up for just a few weeks over christmas I gained three pounds. I mean...dang...it comes off so hard but goes on so easily.

Could the deck literally be stacked against some people? I'm intrigued by the fact that in the study the two mice were fed basically the same calories yet one remained slim while the other gained weight. The only thing I can logically attribute that to is an increase in metabolic rate. Anyway...is there more to it than we know? Are they on to something with this gut bacteria thing?
 
How does a person actually go about becoming a poop donor? I mean...is there a place that you can actually go to just like a sperm bank? Well...without the magazines and everything.

I'm not sure of all the details, but fecal transplant is utilized in difficult cases. I guess since my buddy was up to date on his vaccines and was the lowest member on the hierarchy of the admitting team, they asked him if he'd poop in a specimen bag for the patient and he went for it.

When I was an intern we had one case where we were close to doing this, but he started responding to oral vancomycin so we didn't have to resort to it.
 
I'm not sure of all the details, but fecal transplant is utilized in difficult cases. I guess since my buddy was up to date on his vaccines and was the lowest member on the hierarchy of the admitting team, they asked him if he'd poop in a specimen bag for the patient and he went for it.

When I was an intern we had one case where we were close to doing this, but he started responding to oral vancomycin so we didn't have to resort to it.

Mud butt for a good cause
 
And on a serious note Carl...being a doctor, what are your thoughts on these studies finding evidence that our gut biome might be important in weight gain or loss? I have lived the last year using the premise calories in-calories out. That seems to be the key at the end of the day. So after a year of walking daily (my Fitbit history has me at over 43,150,000 steps in the last year), lifting weights four days a week, and counting calories daily I've lost about 40 pounds. But after loosening up for just a few weeks over christmas I gained three pounds. I mean...dang...it comes off so hard but goes on so easily.

Could the deck literally be stacked against some people? I'm intrigued by the fact that in the study the two mice were fed basically the same calories yet one remained slim while the other gained weight. The only thing I can logically attribute that to is an increase in metabolic rate. Anyway...is there more to it than we know? Are they on to something with this gut bacteria thing?

It's really too far from my area of expertise to know much about it...but I still think that for the majority of obese people (or on a population/cultural level), that the law of thermodynamics trumps all.

Sure, you've got some people with thyroid or maybe gut biome may be the culprit, but even the most optimal of gut bacteria flora will have a hard time making up for a large caloric surplus with insulin-spiking processed carbs.
 
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